Foot and ankle pain can result from degenerative changes or injury to muscle, tendon, nerves, and/or joints. Other causes include infection, lupus, and inadequate alignment of the lower extremity. Pain that impacts the foot and ankle is one of the most debilitating and dysfunctional states.

Foot pain may profoundly affect normal function and movement. It may be associated with a wide range of factors, including conditions such as arthritis, injury, mechanical damage, and nerve damage. As foot pain is processed by sacral or lumbar nerves, many treatments for this type of pain may target them directly. These include nerve blocks, spinal cord stimulation, and radiofrequency ablation. Other treatments include steroid therapy and joint injections, for cases of foot pain related to arthritis.